Matthew J. Budoff, M.D., one of the study's authors and a researcher at the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed), said previous studies had found measuring coronary arterial calcium with computed tomography (CT) heart scans could predict overall death risks in most American adults.
He said the latest study is the first extensive examination of coronary arterial scans of the elderly.
"This study indicates calcium scans can be the best predictor currently available to detect who is likely to suffer a heart attack and who is not," said Dr. Budoff. "Previous studies found coronary arterial calcium scans were effective tools for determining the overall death risk in young adults, diabetics, smokers and those suffering from renal failure. This study indicates coronary arterial scans are effective in measuring overall death risk in the elderly."
A calcium scan looks for calcification - or a hardening of the arteries caused by high blood fats and calcium deposits - in the arteries leading to and from the heart. These calcifications can block blood vessels and cause heart attacks, strokes or other health issues.
Researchers studied 35,383 adults, aged 40 to 80, in Torrance, CA and Nashville, TN, for an average of 5.8 years after having a coronary artery calcium scan. Among these research volunteers, 3,570 were age 70 or older.
In total, 838 deaths were recorded, 320 in women and 518 in men. The study found the overall death risk was higher among those with higher coronary arterial calcium scores.
"This study provides additional validation of coronary calcium studies," said Dr. Budoff. "Coronary arterial calcium scans can be very useful tools in assessing a patient's overall death risk. With this information, physicians can advise patients on diet, medications, exercise and other lifestyle changes that will help them avoid the risk of heart attack, strokes and other health problems."
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Resveratrol did not have a significant effect on lifespan in animals fed standard chow, suggesting that the intervention did not affect all aspects of the basic aging process. Mice on a high-calorie diet without resveratrol lived the shortest length of time and mice on an every-other-day regimen lived the longest, regardless of resveratrol treatment. However, for mice on a high-calorie diet, mean and maximum lifespan increased for mice on resveratrol when compared with the control mice. Researchers found that resveratrol's effects on longevity could be completely uncoupled from changes in body weight, meaning that mice on a high-calorie diet with resveratrol did not necessarily lose weight but did experience a longer (and healthier) life than mice on the same high-calorie diet not taking resveratrol. They speculate that improved cardiovascular health and reduced fatty changes in the liver may have contributed to the increased lifespan of resveratrol-treated mice.
Researchers still have much to learn before resveratrol can be recommended for human use. Basic questions of safety and biological effect in humans remain to be studied experimentally.
"We are learning a great deal about how resveratrol affects the health and survival of mammals," said Sinclair. "Continued study of calorie restriction mimetics such as resveratrol may eventually point the way to new medicines to treat diseases of aging."
In addition to scientists from the NIA and Harvard Medical School, researchers from the following institutions collaborated in this study: New York Medical College, Valhalla, N.Y.; University of Michigan, Ann Arbor; University of Sydney in Australia; Thomas Jefferson University, Philadelphia; University of California, San Diego, La Jolla; Hospital for Special Surgery, New York, N.Y.; University of Cincinnati, Ohio; University of Texas Health Science Center at San Antonio and Audie Murphy VA Hospital, San Antonio, Texas; Universidad Pablo de Olavide, Sevilla, Spain; Pennington Biomedical Research Center, Baton Rouge, La.; University of Washington, Seattle; and Sirtris Pharmaceuticals of Cambridge, Mass., a company founded by Harvard University co-lead author Sinclair.
De Cabo is a scientist in the NIA's Intramural Research Program. In addition, the research was funded by grants from the NIA, the primary supporter of the work, as well as grants from the National Institute of General Medical Sciences; the National Heart, Lung, and Blood Institute; the National Institute of Child Health and Human Development; the National Eye Institute; and the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the NIH. The Ellison Medical Research Foundation, the American Heart Association, the Australian and Spanish governments and Paul F. Glenn and The Paul F. Glenn Laboratories for the Biological Mechanisms of Aging also provided support to members of the research team.
The NIA leads the federal government effort conducting and supporting research on the biomedical and social and behavioral aspects of aging and the problems of older people.
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